Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people.
Identifieur interne : 003D11 ( Main/Exploration ); précédent : 003D10; suivant : 003D12Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people.
Auteurs : Alison R. Yung [Australie] ; Carrie Stanford ; Elizabeth Cosgrave ; Eoin Killackey ; Lisa Phillips ; Barnaby Nelson ; Patrick D. McgorrySource :
- Schizophrenia research [ 0920-9964 ] ; 2006.
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Abstract
Criteria for identifying individuals at imminent risk for onset of a psychotic disorder, that is "prodromal" for psychosis, have recently been described. The current study set out to test the predictive validity of these criteria in a sample of help-seeking young people aged 15-24 years who were referred to, but not necessarily treated at, a psychiatric service. Ultra High Risk (UHR) status was determined at baseline and psychosis status was assessed at 6 month follow up. Baseline psychosocial functioning was also assessed as a possible predictor of psychosis. In the sample of 292 individuals, 119 (40.7%) met UHR criteria. Of these UHR+ people, 12 became psychotic within 6 months and 107 did not. Only one person not meeting UHR criteria developed psychosis in the follow up period. Sensitivity, specificity, positive predictive value and negative predictive value of UHR+ status for prediction of psychosis were, respectively, 0.923 (95% CI 0.621, 1), 0.616 (95% CI 0.556, 0.673), 0.101 (95% CI 0.056, 0.173) and 0.994 (95% CI 0.963, 1). UHR+ individuals were significantly more likely to become psychotic than UHR- individuals (Odds Ratio 19.3, 95% CI 2.5, 150.5). Low functioning at baseline was associated with psychosis onset in the whole sample and in the UHR group. The transition to psychosis rate was much lower than in previous samples. This may be a due to the sample being a more general one, not identified as possibly "prodromal". Other potential causes of this reduction in transition are also explored.
DOI: 10.1016/j.schres.2006.03.014
PubMed: 16630707
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Yung</name><affiliation wicri:level="1"><nlm:affiliation>ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia. aryung@unimelb.edu.au</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Stanford, Carrie" sort="Stanford, Carrie" uniqKey="Stanford C" first="Carrie" last="Stanford">Carrie Stanford</name></author><author><name sortKey="Cosgrave, Elizabeth" sort="Cosgrave, Elizabeth" uniqKey="Cosgrave E" first="Elizabeth" last="Cosgrave">Elizabeth Cosgrave</name></author><author><name sortKey="Killackey, Eoin" sort="Killackey, Eoin" uniqKey="Killackey E" first="Eoin" last="Killackey">Eoin Killackey</name></author><author><name sortKey="Phillips, Lisa" sort="Phillips, Lisa" uniqKey="Phillips L" first="Lisa" last="Phillips">Lisa Phillips</name></author><author><name sortKey="Nelson, Barnaby" sort="Nelson, Barnaby" uniqKey="Nelson B" first="Barnaby" last="Nelson">Barnaby Nelson</name></author><author><name sortKey="Mcgorry, Patrick D" sort="Mcgorry, Patrick D" uniqKey="Mcgorry P" first="Patrick D" last="Mcgorry">Patrick D. Mcgorry</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16630707</idno><idno type="pmid">16630707</idno><idno type="doi">10.1016/j.schres.2006.03.014</idno><idno type="wicri:Area/Main/Corpus">003E22</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">003E22</idno><idno type="wicri:Area/Main/Curation">003E22</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">003E22</idno><idno type="wicri:Area/Main/Exploration">003E22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people.</title><author><name sortKey="Yung, Alison R" sort="Yung, Alison R" uniqKey="Yung A" first="Alison R" last="Yung">Alison R. Yung</name><affiliation wicri:level="1"><nlm:affiliation>ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia. aryung@unimelb.edu.au</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Stanford, Carrie" sort="Stanford, Carrie" uniqKey="Stanford C" first="Carrie" last="Stanford">Carrie Stanford</name></author><author><name sortKey="Cosgrave, Elizabeth" sort="Cosgrave, Elizabeth" uniqKey="Cosgrave E" first="Elizabeth" last="Cosgrave">Elizabeth Cosgrave</name></author><author><name sortKey="Killackey, Eoin" sort="Killackey, Eoin" uniqKey="Killackey E" first="Eoin" last="Killackey">Eoin Killackey</name></author><author><name sortKey="Phillips, Lisa" sort="Phillips, Lisa" uniqKey="Phillips L" first="Lisa" last="Phillips">Lisa Phillips</name></author><author><name sortKey="Nelson, Barnaby" sort="Nelson, Barnaby" uniqKey="Nelson B" first="Barnaby" last="Nelson">Barnaby Nelson</name></author><author><name sortKey="Mcgorry, Patrick D" sort="Mcgorry, Patrick D" uniqKey="Mcgorry P" first="Patrick D" last="Mcgorry">Patrick D. Mcgorry</name></author></analytic><series><title level="j">Schizophrenia research</title><idno type="ISSN">0920-9964</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Female (MeSH)</term><term>Follow-Up Studies (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Patient Acceptance of Health Care (MeSH)</term><term>Predictive Value of Tests (MeSH)</term><term>Psychotic Disorders (diagnosis)</term><term>Risk Factors (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acceptation des soins par les patients (MeSH)</term><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Troubles psychotiques (diagnostic)</term><term>Valeur prédictive des tests (MeSH)</term><term>Études de suivi (MeSH)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Psychotic Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Troubles psychotiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Patient Acceptance of Health Care</term><term>Predictive Value of Tests</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acceptation des soins par les patients</term><term>Adolescent</term><term>Adulte</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Valeur prédictive des tests</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Criteria for identifying individuals at imminent risk for onset of a psychotic disorder, that is "prodromal" for psychosis, have recently been described. The current study set out to test the predictive validity of these criteria in a sample of help-seeking young people aged 15-24 years who were referred to, but not necessarily treated at, a psychiatric service. Ultra High Risk (UHR) status was determined at baseline and psychosis status was assessed at 6 month follow up. Baseline psychosocial functioning was also assessed as a possible predictor of psychosis. In the sample of 292 individuals, 119 (40.7%) met UHR criteria. Of these UHR+ people, 12 became psychotic within 6 months and 107 did not. Only one person not meeting UHR criteria developed psychosis in the follow up period. Sensitivity, specificity, positive predictive value and negative predictive value of UHR+ status for prediction of psychosis were, respectively, 0.923 (95% CI 0.621, 1), 0.616 (95% CI 0.556, 0.673), 0.101 (95% CI 0.056, 0.173) and 0.994 (95% CI 0.963, 1). UHR+ individuals were significantly more likely to become psychotic than UHR- individuals (Odds Ratio 19.3, 95% CI 2.5, 150.5). Low functioning at baseline was associated with psychosis onset in the whole sample and in the UHR group. The transition to psychosis rate was much lower than in previous samples. This may be a due to the sample being a more general one, not identified as possibly "prodromal". Other potential causes of this reduction in transition are also explored.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16630707</PMID><DateCompleted><Year>2006</Year><Month>09</Month><Day>08</Day></DateCompleted><DateRevised><Year>2016</Year><Month>05</Month><Day>26</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0920-9964</ISSN><JournalIssue CitedMedium="Print"><Volume>84</Volume><Issue>1</Issue><PubDate><Year>2006</Year><Month>May</Month></PubDate></JournalIssue><Title>Schizophrenia research</Title><ISOAbbreviation>Schizophr Res</ISOAbbreviation></Journal><ArticleTitle>Testing the Ultra High Risk (prodromal) criteria for the prediction of psychosis in a clinical sample of young people.</ArticleTitle><Pagination><MedlinePgn>57-66</MedlinePgn></Pagination><Abstract><AbstractText>Criteria for identifying individuals at imminent risk for onset of a psychotic disorder, that is "prodromal" for psychosis, have recently been described. The current study set out to test the predictive validity of these criteria in a sample of help-seeking young people aged 15-24 years who were referred to, but not necessarily treated at, a psychiatric service. Ultra High Risk (UHR) status was determined at baseline and psychosis status was assessed at 6 month follow up. Baseline psychosocial functioning was also assessed as a possible predictor of psychosis. In the sample of 292 individuals, 119 (40.7%) met UHR criteria. Of these UHR+ people, 12 became psychotic within 6 months and 107 did not. Only one person not meeting UHR criteria developed psychosis in the follow up period. Sensitivity, specificity, positive predictive value and negative predictive value of UHR+ status for prediction of psychosis were, respectively, 0.923 (95% CI 0.621, 1), 0.616 (95% CI 0.556, 0.673), 0.101 (95% CI 0.056, 0.173) and 0.994 (95% CI 0.963, 1). UHR+ individuals were significantly more likely to become psychotic than UHR- individuals (Odds Ratio 19.3, 95% CI 2.5, 150.5). Low functioning at baseline was associated with psychosis onset in the whole sample and in the UHR group. The transition to psychosis rate was much lower than in previous samples. This may be a due to the sample being a more general one, not identified as possibly "prodromal". Other potential causes of this reduction in transition are also explored.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yung</LastName><ForeName>Alison R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>ORYGEN Research Centre, 35 Poplar Rd Parkville 3052, Victoria, Australia. aryung@unimelb.edu.au</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stanford</LastName><ForeName>Carrie</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Cosgrave</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Killackey</LastName><ForeName>Eoin</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Phillips</LastName><ForeName>Lisa</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Nelson</LastName><ForeName>Barnaby</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>McGorry</LastName><ForeName>Patrick D</ForeName><Initials>PD</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2006</Year><Month>04</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Schizophr Res</MedlineTA><NlmUniqueID>8804207</NlmUniqueID><ISSNLinking>0920-9964</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010342" MajorTopicYN="N">Patient Acceptance of Health Care</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011618" MajorTopicYN="N">Psychotic Disorders</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>12</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2006</Year><Month>03</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2006</Year><Month>03</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>4</Month><Day>25</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>9</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>4</Month><Day>25</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16630707</ArticleId><ArticleId IdType="pii">S0920-9964(06)00108-3</ArticleId><ArticleId IdType="doi">10.1016/j.schres.2006.03.014</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Cosgrave, Elizabeth" sort="Cosgrave, Elizabeth" uniqKey="Cosgrave E" first="Elizabeth" last="Cosgrave">Elizabeth Cosgrave</name><name sortKey="Killackey, Eoin" sort="Killackey, Eoin" uniqKey="Killackey E" first="Eoin" last="Killackey">Eoin Killackey</name><name sortKey="Mcgorry, Patrick D" sort="Mcgorry, Patrick D" uniqKey="Mcgorry P" first="Patrick D" last="Mcgorry">Patrick D. Mcgorry</name><name sortKey="Nelson, Barnaby" sort="Nelson, Barnaby" uniqKey="Nelson B" first="Barnaby" last="Nelson">Barnaby Nelson</name><name sortKey="Phillips, Lisa" sort="Phillips, Lisa" uniqKey="Phillips L" first="Lisa" last="Phillips">Lisa Phillips</name><name sortKey="Stanford, Carrie" sort="Stanford, Carrie" uniqKey="Stanford C" first="Carrie" last="Stanford">Carrie Stanford</name></noCountry><country name="Australie"><noRegion><name sortKey="Yung, Alison R" sort="Yung, Alison R" uniqKey="Yung A" first="Alison R" last="Yung">Alison R. Yung</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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